NF- B Regulates Spatial Memory Formation and Synaptic Plasticity through Protein Kinase A/CREB Signaling
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چکیده
NFB Regulates Spatial Memory Formation and Synaptic Plasticity through Protein Kinase A/CREB Signaling Barbara Kaltschmidt, Delphine Ndiaye, Martin Korte,† Stéphanie Pothion, Laurence Arbibe,‡ Maria Prüllage, Julia Pfeiffer, Antje Lindecke, Volker Staiger, Alain Israël, Christian Kaltschmidt,* and Sylvie Mémet* Institut für Neurobiochemie, Universität Witten/Herdecke, Stockumer Strasse 10, D-58448 Witten, Germany; Unité de Biologie Moléculaire de l’Expression Génique, URA CNRS 2582, Institut Pasteur, 25 rue du Dr Roux, 75724 Paris Cedex 15, France; Max-Planck-Institut für Neurobiologie, Department of Cellular and Systems Neurobiology, Am Klopferspitz 18a, D-82152 Martinsried, Germany; and Key-Obs SA, Centre d’Innovation, 16 rue Léonard de Vinci, 45074 Orléans Cedex 2, France
منابع مشابه
NF-kappaB regulates spatial memory formation and synaptic plasticity through protein kinase A/CREB signaling.
Synaptic activity-dependent de novo gene transcription is crucial for long-lasting neuronal plasticity and long-term memory. In a forebrain neuronal conditional NF-kappaB-deficient mouse model, we demonstrate here that the transcription factor NF-kappaB regulates spatial memory formation, synaptic transmission, and plasticity. Gene profiling experiments and analysis of regulatory regions identi...
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